亚洲免费在线观看_亚洲无码国产精品_亚洲蜜桃精久久久久久久久久久久_欧美性猛交XXXXX水多

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
中文字幕1区2区3区4区,精品国产伦一区二区三区观看体验
首頁(yè) > 產(chǎn)品中心 > 一抗 > 產(chǎn)品信息
MGMT Rabbit pAb (bs-1002R)  
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@bioss.com.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價(jià)

產(chǎn)品編號(hào) bs-1002R
英文名稱 MGMT Rabbit pAb
中文名稱 O6甲基鳥嘌呤DNA甲基轉(zhuǎn)移酶抗體
別    名 6 O methylguanine DNA methyltransferase; Agat; AGT; AI267024; EC 2.1.1.63; Methylated DNA protein cysteine methyltransferase; Methylguanine DNA methyltransferase; MGC107020; MGMT: O-6 methylguanine DNA methyltransferase; O 6 methylguanine DNA alkyltransferase; O 6 methylguanine DNA methyltransferase; O-6 methylguanine DNA alkyltransferase; O-6-methylguanine-DNA methyltransferase; O6 methylguanine DNA methyltransferase; MGMT_HUMAN.  
Specific References  (3)     |     bs-1002R has been referenced in 3 publications.
[IF=3.61] Oláh, Zita, et al. "Proteomic Analysis of Cerebrospinal Fluid in Alzheimers Disease: Wanted Dead or Alive." Journal of Alzheimers Disease (2014).  WB ;  Human.  
[IF=2.98] Li et al. Effects of low-intensity ultrasound combined with low-dose carboplatin in an orthotopic hamster model of tongue cancer: A preclinical study. (2018) Oncol.Rep. 39:1609-1618  IHC,WB ;  Hamsters.  
[IF=2.886] Yusi Liu. et al. Synergistic Effects of Resveratrol and Temozolomide Against Glioblastoma Cells: Underlying Mechanism and Therapeutic Implications. Cancer Manag Res. 2020; 12: 8341–8354  ICC ;  Rat, Human.  
研究領(lǐng)域 腫瘤  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
克 隆 號(hào)
交叉反應(yīng) Rat (predicted: Human,Mouse)
產(chǎn)品應(yīng)用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 22 kDa
檢測(cè)分子量
細(xì)胞定位 細(xì)胞核 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human MGMT: 101-207/207 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 MGMT (O6 methylguanine DNA methyltransferase) is an enzyme that transfers methyl groups from O(6) methylguanine, and other methylated moities of DNA, to a cysteine residue in itself, thus repairing DNA damage caused by alkylation in a single step reaction. This is a suicide reaction as the enzyme is irreversibly inactivated. MGMT prevents mutagenesis and malignant transformation, and also provides resistance to chemotherapy with alkylating agents among cancer patients.

Function:
Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

Subcellular Location:
Nucleus.

Similarity:
Belongs to the MGMT family.

SWISS:
P16455

Gene ID:
4255

Database links:

Entrez Gene: 4255 Human

Omim: 156569 Human

SwissProt: P16455 Human

Unigene: 501522 Human



O-6-methylguanine-DNA methyltransferase(MGMT)O-6-甲基鳥嘌呤-DNA-甲基轉(zhuǎn)移酶:是廣泛存在于細(xì)菌到哺乳動(dòng)物機(jī)體中的一種獨(dú)特DNA修復(fù)酶,MGMT是一種DNA修復(fù)酶,是突變和癌變的抑制因子。它對(duì)烷化劑導(dǎo)致的DNA損傷有修復(fù)作用。
MGMT是突變和癌基因的抑制因子。研究表明MGMT水平與惡性腫瘤的發(fā)生、進(jìn)展、浸潤(rùn)、預(yù)后及治療有密切關(guān)系。細(xì)胞中MGMT水平與其所能耐受的DNA損傷密切相關(guān)。一般來(lái)講,低水平表達(dá)MGMT的腫瘤可以應(yīng)用烷化劑藥物治療;反之則為耐藥。在正常組織中,肝臟高表達(dá);腦組織和骨髓低水平表達(dá)。
產(chǎn)品圖片
Tissue/cell: rat liver tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-MGMT Polyclonal Antibody, Unconjugated(bs-1002R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
Tissue/cell: rat brain tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-MGMT Polyclonal Antibody, Unconjugated(bs-1002R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
版權(quán)所有 2004-2026 cqshengou.com 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)