| 產(chǎn)品編號 | bs-1065R |
| 英文名稱 | C9orf127 Rabbit pAb |
| 中文名稱 | 鼻咽癌細(xì)胞相關(guān)基因6抗體 |
| 別 名 | NGX6; 4930500O05Rik; C9orf127; MGC120460; NAG-5; NGX6; RGD1310012; RP11-112J3.10; TMEM8B; nasopharyngeal carcinoma; NPC associated gene 6; TMM8B_HUMAN; chromosome 9 open reading frame 127; NAG 5; Nasopharyngeal carcinoma expressed 6; Nasopharyngeal carcinoma related protein; Nasopharyngeal carcinoma-associated gene 6 protein; Protein NAG-5; Protein NGX6; RP11-112J3.10; RP11-112J3.10-001; TMEM8B; Transmembrane protein 8B . |
| 研究領(lǐng)域 | 腫瘤 轉(zhuǎn)錄調(diào)節(jié)因子 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 克 隆 號 | |
| 交叉反應(yīng) | Human (predicted: Mouse,Rat,Cow) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 52 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞核 細(xì)胞漿 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human NGX6: 21-120/472 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
NGX6 (nasopharyngeal carcinoma/NPC associated gene 6) may function as a regulator of the EGFR pathway. Probable tumor suppressor which may function in cell growth, proliferation and adhesion. [SUBUNIT] Isoform 2 (via its cytoplasmic part) interacts with EZR. [SUBCELLULAR LOCATION] Isoform 2: Cell membrane; Multi-pass membrane protein (Probable). Cytoplasm (Probable). Nucleus (Probable). Mitochondrion. Endoplasmic reticulum. Belongs to the NGX6 family. The down-regulation of C9orf127 may be closely associated with tumorigenesis and metastasis of colorectal carcinoma. However, it may not contribute to the development and progression of gastric carcinoma. Function: May function as a regulator of the EGFR pathway. Probable tumor suppressor which may function in cell growth, proliferation and adhesion. Subunit: Isoform 2 (via its cytoplasmic part) interacts with EZR. Subcellular Location: Cell membrane. Cytoplasm. Nucleus. Mitochondrion. Endoplasmic reticulum. Also detected in mitochondrion and endoplasmic reticulum. Post-translational modifications: Isoform 2 is N-glycosylated. Similarity: Belongs to the TMEM8 family. Contains 1 EGF-like domain. SWISS: A6NDV4 Gene ID: 51754 Database links: Entrez Gene: 51754 Human Entrez Gene: 242409 Mouse SwissProt: A6NDV4 Human SwissProt: B1AWJ5 Mouse Unigene: 493808 Human Unigene: 171489 Mouse NGX6是鼻咽癌發(fā)生和發(fā)展重要的相關(guān)蛋白,NGX-6作用于鼻咽癌細(xì)胞，抗體可用于鼻咽癌診斷。有學(xué)者認(rèn)為：NGX6也表達(dá)在部分消化系統(tǒng)的腫瘤中。 |
| 產(chǎn)品圖片 |
Tissue/cell: human nasopharyngeal carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-NGX6/C9orf127 Polyclonal Antibody, Unconjugated(bs-1065R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
|
