| 產(chǎn)品編號(hào) | bs-0446R |
| 英文名稱 | FOXE1 Rabbit pAb |
| 中文名稱 | 甲狀腺轉(zhuǎn)錄因子-2抗體 |
| 別 名 | FKH L15; FKHL 15; FKHL15; Forkhead(Drosophila) like 15; forkhead(Drosophila)-like 15; forkhead box E1; Forkhead box E2; Forkhead box protein E1; Forkhead drosophila homolog like 15; Forkhead like 15; Forkhead related protein FKHL 15; Forkhead related protein FKHL15; FOX E1; FOX E2; FOXE 1; FOXE 2; FOXE-2; FOXE1; FOXE2; HFKH 4; HFKH4; HFKL 5; HFKL5; homolog-like 15; thyroid transcription factor 2; thyroid transcription factor-2; TITF 2; TITF2; TTF 2; TTF-2; TTF2; FOXE1_HUMAN. |
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Specific References (4) | bs-0446R has been referenced in 4 publications.
[IF=5.051] Lim Grace. et al. Foxe1 Deletion in the Adult Mouse is Associated with Increased Thyroidal Mast Cells and Hypothyroidism. ENDOCRINOLOGY. 2022 Sep;: IHC, WB ; Mouse.
[IF=4.223] Dong, Xinwen. et al. Protective effects of curcumin against thyroid hormone imbalance after gas explosion-induced traumatic brain injury via activation of the hypothalamic-pituitary-thyroid axis in male rats. ENVIRON SCI POLLUT R. 2022 May;:1-13 WB ; Rat.
[IF=3.644] Ran Q et al. Generation of Thyroid Tissues From Embryonic Stem Cells via Blastocyst Complementation In VivoFront Endocrinol (Lausanne).2020 Dec 14;11:609697. IF ; Mouse.
[IF=3.58] Wang, Qi, et al. "Methamphetamine induces hepatotoxicity via inhibiting cell division, arresting cell cycle and activating apoptosis: In vivo and in vitro studies." Food and Chemical Toxicology (2017). WB ; Rat.
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| 研究領(lǐng)域 | 轉(zhuǎn)錄調(diào)節(jié)因子 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 克 隆 號(hào) | |
| 交叉反應(yīng) | Mouse (predicted: Human,Rat,Pig,Cow,Chicken,Dog) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 41 kDa |
| 檢測(cè)分子量 | |
| 細(xì)胞定位 | 細(xì)胞核 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human FOXE1: 101-200/373 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Thyroid transcription factor 2 (TITF2; Forkhead; TH; also known as a "winged helix") . FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as monomers, are also found in the Hepatocyte nuclear factor (HNF) proteins, which provide tissue-specific gene regulation. The structure contains 2 flexible loops or "wings" in the C-terminal region, hence the term winged helix. Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. TISSUE SPECIFICITY: Thyroid and lung. subcellular location: Nucleus Belongs to the NK-2 homeobox family. Function: Probable transcription factor. Could be involved in thyroid gland organogenesis. Subcellular Location: Nucleus (Potential). Tissue Specificity: Detected in adult brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, heart, colon, small intestine testis and thymus. Expression was strongest in heart and pancreas. Post-translational modifications: Phosphorylated. DISEASE: Defects in FOXE1 are the cause of Bamforth-Lazarus syndrome (BLS) [MIM:241850]. BLS is associated with thyroid agenesis, cleft palate and choanal atresia. Similarity: Contains 1 fork-head DNA-binding domain. SWISS: O00358 Gene ID: 2304 Database links: Entrez Gene: 2304 Human GenBank: NP_004464 Human Omim: 602617 Human SwissProt: O00358 Human Unigene: 159234 Human 甲狀腺轉(zhuǎn)錄因子-2(TTF-2)在個(gè)體發(fā)生中的表達(dá)具有高度組織特異性和發(fā)育階段特異性,是甲狀腺、腭等器官正常發(fā)育的重要調(diào)節(jié)因子。 只要用于研究TTF-2基因活動(dòng)規(guī)律和表達(dá)模式發(fā)生的變化,對(duì)胚胎發(fā)育過程中器官發(fā)生和產(chǎn)生的影響狀況。 |
| 產(chǎn)品圖片 |
Sample:
Kidney (Mouse) Lysate at 40 ug
Primary: Anti-FOXE1 (bs-0446R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 41 kD
Observed band size: 41 kD
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