| 產(chǎn)品編號(hào) | bs-1695R |
| 英文名稱 | Decorin Rabbit pAb |
| 中文名稱 | 核心蛋白聚糖抗體 |
| 別 名 | Bone proteoglycan II; CSCD; DCN; DCN protein; Dermatan sulphate proteoglycans II; DKFZp686J19238; DSPG 2; DSPG2; PG 40; PG II; PG S2; PG-S2; PG40; PGII; PGS 2; PGS2; Proteoglycan core protein; SLRR1B; Small leucine rich protein 1B; PGS2_HUMAN. |
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Specific References (5) | bs-1695R has been referenced in 5 publications.
[IF=3.71] Bakker, Erik NTP, et al. "Heterogeneity in Arterial Remodeling among Sublines of Spontaneously Hypertensive Rats." PLoS one 9.9 (2014): e107998. IHC-F ; Rat.
[IF=3.61] Li, Guoqing, et al. "Identifying DCN and HSPD1 as Potential Biomarkers in Colon Cancer Using 2D-LC-MS/MS Combined with iTRAQ Technology." Journal of Cancer 8.3 (2017): 479-489. IHC-P ; Human.
[IF=2.17] Peng, J. Y., et al. "Molecular cloning, expression analysis, and function of decorin in goat ovarian granulosa cells." Domestic Animal Endocrinology (2016). WB, IHC-P ; Goat.
[IF=2.16] Li, Xinxin, et al. "Long-term thermal manipulation in the late incubation period can inhibit breast muscle development by activating endoplasmic reticulum stress in duck (Anasplatyrhynchos domestica)." Journal of thermal biology 70.Pt B (2017): 37. WB ; Other Species.
[IF=1.566] Shibata S et al. Immunohistochemical?and?ultrastructural?evaluation?of?matrix?components?in?mandibularcondylar?cartilage?in?comparison?with?growth?plate?cartilage?in?cartilage?calcification insufficient rats. Anat Sci Int. 2019 Jun 14. IHC-P ; Rat.
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| 研究領(lǐng)域 | 轉(zhuǎn)錄調(diào)節(jié)因子 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 克 隆 號(hào) | |
| 交叉反應(yīng) | Human (predicted: Mouse,Rat,Rabbit,Pig,Sheep,Cow,Chicken,GuineaPig,Horse) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 36 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞外基質(zhì) 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human DCN: 101-200/347 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Decorin is a member of the small, leucine rich proteoglycan (SLRP) family along with biglycan. Found in the interterritorial region of cartilage, decorin interacts with collagen and other matrix proteins to regulate the cartilaginous matrix. It has been shown to interact with fibronectin, thrombospondin, C1q, epidermal growth factor receptor (EGFR), and TGF beta. It is believed that decorin also plays a role in the cell cycle of chondrocytes. Also known as: Decorin; Bone proteoglycan II; CSCD; DCN; DCN protein; Dermatan sulphate proteoglycans II; DKFZp686J19238; DSPG 2; DSPG2; PG 40; PG II; PG S2; PG40; PGII; PGS 2; PGS2; Proteoglycan core protein; SLRR1B; Small leucine rich protein 1B. Function: May affect the rate of fibrils formation. Subunit: Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN. Interacts with DPT (By similarity). Subcellular Location: Secreted, extracellular space, extracellular matrix. Post-translational modifications: The attached glycosaminoglycan chain can be either chondroitin sulfate or dermatan sulfate depending upon the tissue of origin. DISEASE: Defects in DCN are the cause of congenital stromal corneal dystrophy (CSCD) [MIM:610048]. Corneal dystrophies are inherited, bilateral, primary alterations of the cornea that are not associated with prior inflammation or secondary to systemic disease. Most show autosomal dominant inheritance. Similarity: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. Contains 12 LRR (leucine-rich) repeats. SWISS: P07585 Gene ID: 1634 Database links: Entrez Gene: 1634 Human Entrez Gene: 13179 Mouse Omim: 125255 Human SwissProt: P07585 Human SwissProt: P28654 Mouse Unigene: 728830 Human Unigene: 56769 Mouse Unigene: 106103 Rat 核心蛋白聚糖(decorin)屬高分子蛋白多糖類，為蛋白聚糖(PG)的一種,是轉(zhuǎn)化生長因子β(TGFβ)的拮抗劑。Decorin在調(diào)節(jié)細(xì)胞粘附、遷移、增殖、膠原纖維形成活性調(diào)節(jié)及對TGF-β的負(fù)反饋調(diào)節(jié)中起到一定的作用。 |
| 產(chǎn)品圖片 |
Sample:
Lane 1: Human U2os cell lysates
Lane 2: Human Huvec cell lysates
Primary: Anti-Decorin (bs-1695R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 36 kD
Observed band size: 110 kD
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