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LUCA15 Rabbit pAb (bs-6090R)  
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產(chǎn)品編號(hào) bs-6090R
英文名稱 LUCA15 Rabbit pAb
中文名稱 腫瘤抑制基因LUCA15抗體
別    名 G15 antibody H37 antibody LUCA 15; LUCA15; Protein G15; RBM 5; Renal carcinoma antigen NY REN 9; RMB 5; RMB5; RNA binding motif protein 5; RNA binding protein 5; Tumor suppressor LUCA15; RBM5_HUMAN.  
研究領(lǐng)域 腫瘤  細(xì)胞生物  染色質(zhì)和核信號(hào)  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞凋亡  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Rat (predicted: Human,Mouse,Rabbit,Pig,Cow,Dog,Horse)
產(chǎn)品應(yīng)用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 92 kDa
檢測(cè)分子量
細(xì)胞定位 細(xì)胞核 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human RBM5/LUCA15: 731-815/815 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 RBM5 (RNA binding motif protein 5) is a nuclear SR related RNA binding protein which specifically binds poly(G) RNA homopolymers in vitro. It modulates both apoptosis and the cell cycle, and retards tumor formation.

Subunit:
Component of the spliceosome A complex (also known as the prespliceosome). Appears to dissociate from the spliceosome upon formation of the spliceosome B complex (also known as the precatalytic spliceosome), in which the heterotrimeric U4/U6.U5 snRNPs are bound. Interacts with U2AF2; this interaction is direct. Also interacts with ACIN1, PRPF8, SFRS3, SNRPB, SNRPN, SNRNP70 and SNRNP200; these interactions may be indirect.

Subcellular Location:
Nuclear.

Tissue Specificity:
Isoform 5 is widely expressed in normal tissues and is expressed at increased levels in T-leukemic cell lines.

Similarity:
Belongs to the RBM5/RBM10 family.
Contains 1 C2H2-type zinc finger.
Contains 1 G-patch domain.
Contains 1 RanBP2-type zinc finger.
Contains 2 RRM (RNA recognition motif) domains.

SWISS:
P52756

Gene ID:
10181

Database links:

Entrez Gene: 10181 Human

Entrez Gene: 83486 Mouse

Entrez Gene: 300996 Rat

Omim: 606884 Human

SwissProt: Q1RMU5 Cow

SwissProt: P52756 Human

SwissProt: Q91YE7 Mouse

SwissProt: B2GV05 Rat

Unigene: 439480 Human

Unigene: 259197 Mouse

Unigene: 17033 Rat



產(chǎn)品圖片
Paraformaldehyde-fixed, paraffin embedded (rat thyroid gland); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (LUCA15) Polyclonal Antibody, Unconjugated (bs-6090R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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