| 產(chǎn)品編號(hào) | bs-6225R |
| 英文名稱 | CAMK1D Rabbit pAb |
| 中文名稱 | 鈣調(diào)蛋白激酶CaMK1D抗體 |
| 別 名 | Calcium/calmodulin dependent protein kinase ID; Calcium/calmodulin dependent protein kinase type 1D; CaM K1; CaM KI delta; CaM kinase I delta; CaM kinase ID; CAMK 1D; Camk1D; CaMKI delta; CamKI like protein kinase; CaMKID; CKLiK. |
| 研究領(lǐng)域 | 腫瘤 信號(hào)轉(zhuǎn)導(dǎo) 細(xì)胞凋亡 轉(zhuǎn)錄調(diào)節(jié)因子 激酶和磷酸酶 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human (predicted: Mouse,Rat,Rabbit,Pig,Cow,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 43 kDa |
| 檢測(cè)分子量 | |
| 細(xì)胞定位 | 細(xì)胞核 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CAMK1D: 33-130/385 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
CAMK1D is a member of the Ca2+/calmodulin-dependent protein kinase 1 subfamily of serine/threonine kinases. It may be involved in the regulation of granulocyte function through the chemokine signal transduction pathway and may play a role in apoptosis of erythroleukemia cells. Function: Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta. Subcellular Location: Cytoplasm. Nucleus. Predominantly cytoplasmic (Probable). Also nuclear upon activation. Tissue Specificity: Broadly expressed. Highly and mostly expressed in polymorphonuclear leukocytes (neutrophilic and eosinophilic granulocytes) while little or no expression is observed in monocytes and lymphocytes. Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. Contains 1 protein kinase domain. SWISS: Q8IU85 Gene ID: 57118 Database links: Entrez Gene: 57118 Human Entrez Gene: 227541 Mouse Omim: 607957 Human SwissProt: Q8IU85 Human SwissProt: Q8BW96 Mouse Unigene: 659517 Human Unigene: 191949 Mouse Unigene: 200021 Rat |
| 產(chǎn)品圖片 |
Tissue/cell: human prostate carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-CAMK1D Polyclonal Antibody, Unconjugated(bs-6225R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
|
