| 產(chǎn)品編號 | bs-7566R |
| 英文名稱 | RHBDD3 Rabbit pAb |
| 中文名稱 | 垂體瘤細胞凋亡抗體 |
| 別 名 | C22orf3; HS984G1A; Pituitary tumor apoptosis; PTAG; RHBD3_HUMAN; RHBDD3; Rhomboid domain containing 3; Rhomboid domain-containing protein 3. |
| 研究領(lǐng)域 | 細胞生物 神經(jīng)生物學(xué) 細胞凋亡 轉(zhuǎn)錄調(diào)節(jié)因子 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human,Mouse (predicted: Rat) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 40 kDa |
| 檢測分子量 | |
| 細胞定位 | 細胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human RHBDD3: 151-250/386 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
PTAG is a novel 386 amino acid multi-pass membrane protein that contains one UBA domain and augments drug-induced apoptosis. Cells lacking PTAG have a reduced apoptotic response, thereby causing a predisposition to cell malignancy and resistance to chemotherapeutic interventions, and PTAG plays a role in colorectal tumorigenesis as the majority of primary colorectal tumors lack the PTAG gene. Encoded by a gene located on human chromosome 22, PTAG is often co-expressed with EWS (ewing sarcoma breakpoint region 1), a gene located directly downstream of PTAG. Subcellular Location: Membrane; Multi-pass membrane protein (Potential). Similarity: Contains 1 UBA domain SWISS: Q9Y3P4 Gene ID: 25807 Database links: Entrez Gene: 25807 Human Entrez Gene: 279766 Mouse SwissProt: Q9Y3P4 Human SwissProt: Q8BP97 Mouse Unigene: 106730 Human Unigene: 260866 Mouse Unigene: 9606 Rat RHBDD3分子是一個全新的TLR信號途徑的負向調(diào)控蛋白分子,是一個能夠顯著抑制自身免疫性疾病發(fā)生的效應(yīng)分子,RHBDD3控制機體避免發(fā)生過度的免疫應(yīng)答、防止自身免疫性疾病的發(fā)生具有重要意義。 |
| 產(chǎn)品圖片 |
Sample:
Testis (Mouse) Lysate at 40 ug
Heart (Mouse) Lysate at 40 ug
Liver (Mouse) Lysate at 40 ug
Placenta (Mouse) Lysate at 40 ug
Spleen (Mouse) Lysate at 40 ug
Cerebrum (Mouse) Lysate at 40 ug
Skeletal muscle (Mouse) Lysate at 40 ug
A431(Human) Cell Lysate at 30 ug
HL60(Human) Cell Lysate at 30 ug
A549(Human) Cell Lysate at 30 ug
Molt-4(Human) Cell Lysate at 30 ug
Primary: Anti- RHBDD3 (bs-7566R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 33’51 kD
Observed band size: 51 kD
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