| 產(chǎn)品編號 | bs-16331R |
| 英文名稱 | GSDMA Rabbit pAb |
| 中文名稱 | gasdermin蛋白抗體 |
| 別 名 | FKSG9; Gasdermin 1; Gasdermin A; GSDM; GSDMA_HUMAN; GSDM1. |
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Specific References (2) | bs-16331R has been referenced in 2 publications.
[IF=3.683] Shi, Chenxi. et al. Dihydromyricetin alleviates Escherichia coli lipopolysaccharide-induced hepatic injury in chickens by inhibiting the NLRP3 inflammasome. Vet Res. 2022 Dec;53(1):1-16 WB ; Chicken.
[IF=3.352] Dongming Guo. et al. Hyperactivation of TRPV4 causes the hippocampal pyroptosis pathway and results in cognitive impairment in LPS-treated mice. BEHAV BRAIN RES. 2023 Feb;439:114223 WB ; Mouse.
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| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 細(xì)胞凋亡 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse,Rat (predicted: Human,Cow,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 49 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GSDMA: 21-120/445 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Gasdermin is a 445 amino acid protein that localizes to the perinuclear region of the cytoplasm and belongs to the gasdermin family. Expressed predominately in tissues of the gastrointestinal tract and also present in skin and mammary gland, gasdermin functions to induce apoptosis and is thought to possess tumor suppression activity, specifically in gastric cancer cells. The gene encoding gasdermin maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Function: GSDMA induces apoptosis. Subcellular Location: Cytoplasm, perinuclear region Tissue Specificity: Expressed predominantly in the gastrointestinal tract and in the skin at a lower level. Also detected in mammary gland. Detected in mucus-secreting pit cells of the gastric epithelium. Not expressed in gastric cancer cells. Similarity: Belongs to the gasdermin family. SWISS: Q96QA5 Gene ID: 284110 Database links: Entrez Gene: 284110 Human Entrez Gene: 57911 Mouse Omim: 611218 Human SwissProt: Q96QA5 Human SwissProt: Q9EST1 Mouse |
| 產(chǎn)品圖片 |
Tissue/cell: mouse liver tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-GSDMA Polyclonal Antibody, Unconjugated(bs-16331R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
Tissue/cell: rat rectum tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-GSDMA Polyclonal Antibody, Unconjugated(bs-16331R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
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