| 產(chǎn)品編號 | bs-1695R-APC |
| 英文名稱 | Rabbit Anti-Decorin/APC Conjugated antibody |
| 中文名稱 | APC標(biāo)記的核心蛋白聚糖抗體 |
| 別 名 | Decorin; Bone proteoglycan II; CSCD; DCN; DCN protein; Dermatan sulphate proteoglycans II; DKFZp686J19238; DSPG 2; DSPG2; PG 40; PG II; PG S2; PG-S2; PG40; PGII; PGS 2; PGS2; Proteoglycan core protein; SLRR1B; Small leucine rich protein 1B; PGS2_HUMAN. |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 轉(zhuǎn)錄調(diào)節(jié)因子 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig, ) |
| 產(chǎn)品應(yīng)用 |
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 36kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human DCN |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: Decorin is a member of the small, leucine rich proteoglycan (SLRP) family along with biglycan. Found in the interterritorial region of cartilage, decorin interacts with collagen and other matrix proteins to regulate the cartilaginous matrix. It has been shown to interact with fibronectin, thrombospondin, C1q, epidermal growth factor receptor (EGFR), and TGF beta. It is believed that decorin also plays a role in the cell cycle of chondrocytes. Also known as: Decorin; Bone proteoglycan II; CSCD; DCN; DCN protein; Dermatan sulphate proteoglycans II; DKFZp686J19238; DSPG 2; DSPG2; PG 40; PG II; PG S2; PG40; PGII; PGS 2; PGS2; Proteoglycan core protein; SLRR1B; Small leucine rich protein 1B. Function: May affect the rate of fibrils formation. Subunit: Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN. Interacts with DPT (By similarity). Subcellular Location: Secreted, extracellular space, extracellular matrix. Post-translational modifications: The attached glycosaminoglycan chain can be either chondroitin sulfate or dermatan sulfate depending upon the tissue of origin. DISEASE: Defects in DCN are the cause of congenital stromal corneal dystrophy (CSCD) [MIM:610048]. Corneal dystrophies are inherited, bilateral, primary alterations of the cornea that are not associated with prior inflammation or secondary to systemic disease. Most show autosomal dominant inheritance. Similarity: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. Contains 12 LRR (leucine-rich) repeats. Database links: Entrez Gene: 1634 Human Entrez Gene: 13179 Mouse Omim: 125255 Human SwissProt: P07585 Human SwissProt: P28654 Mouse Unigene: 728830 Human Unigene: 56769 Mouse Unigene: 106103 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 核心蛋白聚糖(decorin)屬高分子蛋白多糖類，為蛋白聚糖(PG)的一種,是轉(zhuǎn)化生長因子β(TGFβ)的拮抗劑。Decorin在調(diào)節(jié)細(xì)胞粘附、遷移、增殖、膠原纖維形成活性調(diào)節(jié)及對TGF-β的負(fù)反饋調(diào)節(jié)中起到一定的作用。 |
