產(chǎn)品編號 | bs-0446R-PE-Cy7 |
英文名稱 | Rabbit Anti-FOXE1/PE-Cy7 Conjugated antibody |
中文名稱 | PE-Cy7標記的甲狀腺轉(zhuǎn)錄因子-2抗體 |
別 名 | FKH L15; FKHL 15; FKHL15; Forkhead (Drosophila) like 15; forkhead (Drosophila)-like 15; forkhead box E1; Forkhead box E2; Forkhead box protein E1; Forkhead drosophila homolog like 15; Forkhead like 15; Forkhead related protein FKHL 15; Forkhead related protein FKHL15; FOX E1; FOX E2; FOXE 1; FOXE 2; FOXE-2; FOXE1; FOXE2; HFKH 4; HFKH4; HFKL 5; HFKL5; homolog-like 15; thyroid transcription factor 2; thyroid transcription factor-2; TITF 2; TITF2; TTF 2; TTF-2; TTF2; FOXE1_HUMAN. |
規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
說 明 書 | 100ul |
研究領域 | 轉(zhuǎn)錄調(diào)節(jié)因子 |
抗體來源 | Rabbit |
克隆類型 | Polyclonal |
交叉反應 | (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, ) |
產(chǎn)品應用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 41kDa |
性 狀 | Lyophilized or Liquid |
濃 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human TTF-2 |
亞 型 | IgG |
純化方法 | affinity purified by Protein A |
儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
產(chǎn)品介紹 |
background: Thyroid transcription factor 2 (TITF2; Forkhead; TH; also known as a "winged helix") . FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as monomers, are also found in the Hepatocyte nuclear factor (HNF) proteins, which provide tissue-specific gene regulation. The structure contains 2 flexible loops or "wings" in the C-terminal region, hence the term winged helix. Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. TISSUE SPECIFICITY: Thyroid and lung. subcellular location: Nucleus Belongs to the NK-2 homeobox family. Function: Probable transcription factor. Could be involved in thyroid gland organogenesis. Subcellular Location: Nucleus (Potential). Tissue Specificity: Detected in adult brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, heart, colon, small intestine testis and thymus. Expression was strongest in heart and pancreas. Post-translational modifications: Phosphorylated. DISEASE: Defects in FOXE1 are the cause of Bamforth-Lazarus syndrome (BLS) [MIM:241850]. BLS is associated with thyroid agenesis, cleft palate and choanal atresia. Similarity: Contains 1 fork-head DNA-binding domain. Database links: Entrez Gene: 2304 Human GenBank: NP_004464 Human Omim: 602617 Human SwissProt: O00358 Human Unigene: 159234 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 甲狀腺轉(zhuǎn)錄因子-2(TTF-2)在個體發(fā)生中的表達具有高度組織特異性和發(fā)育階段特異性,是甲狀腺、腭等器官正常發(fā)育的重要調(diào)節(jié)因子。 只要用于研究TTF-2基因活動規(guī)律和表達模式發(fā)生的變化,對胚胎發(fā)育過程中器官發(fā)生和產(chǎn)生的影響狀況。 |
1、抗體溶解方法 | |
2、抗體修復方式 | |
3、常用試劑的配制 | |
4、免疫組化操作步驟 | |
5、免疫組化問題解答 | |
6、Western Blotting 操作步驟 | |
7、Western Blotting 問題解答 | |
8、關于肽鏈的設計 | |
9、多肽的溶解與保存 | |
10、酶標抗體效價測定程序 | |